At the center of the forest of medicine and palace is present of Bhaisajya-guru which is emanation of wonderful Sakyamuni Buddha and is portrayed as the Supreme Physician. This is on the summit of a mountain endowed with powerful plants for treatment the heat, cold and their combinations. Within a square celestial palace with four gates, in accord with the five excellent conditions the teacher Bhasaja-guru expounds the science of medicine to many assembled retinues, including gods, hermit sages, Hindu divinities and Buddhist adherens. Bhaisajya-guru is a deity whose skin is the deep, blue color of the gemstone lapis lazuli. The gemstone, which is very precious to central Asians, is considered to have divine origins. The deity is holding myrobalan fruit called dug-bcom, which means "that which renders poison inactive" . Dug-bcom is a Tibetan healing symbol and a metaphor for the Three Poisons: desire, hatred and confusion.

The teaching is given in form of a dialogue between two an emanated mental basis Bhaisajya-guru. Bhaisajya-guru and hermit sage (his other mental contents) consider pristine conditions which emanate from the natural glow and consist of the five parts of pristine cognition, namely, the mirror-like pristine cognition which purifies delusion, the pristine cognition of sameness which purifies pride; the pristine cognition of discernment which purifies desire, and the pristine cognition of accomplishment which purifies envy.

This dialogues including the most importance Buddhist medical text, which is used in medical training, is the four-part, 156 chapters rGyud-bzhi or The Four Secret Oral Tantras of the Eight Branches of the Medical Tradition. Master of Remedies , upon heeding the pleas of his fourfold retinue to turn the Wheel of Teaching concerning medical science became absorbed in the non-dual contemplation (samadhi), called "The King of Medicines Who Cures The Four Hundred And Four Diseases". From his heart numerous multi-coloured rays of light were emitted throughout the ten cardinal directions and under their influence the six classes of sentient beings were cleansed of the negativity of evil thought thereby pacifying all diseases and their causes known as the "three poisons": delusion hatred and desire. Then, on the re-absorption of these light-rays, the emanational hermit sage Vidyajnana , who is essentially the embodiment of the Buddha Aksobhyavajra, endowed with the mirror-like pristine cognition (darsajnana), manifested from the buddha-mind or heart-centre of Bhaisajya-guru in the presence of those assembled there. Addressing the Master of Remedies and his attendants, he urged all those wishing to live their lives free from diseases or to eradicate them, to study the science of medicine. Similarly, those persons aspiring to longevity, spiritual accomplishments, liberation, material wealth, and serene living, ought to study the science of medicine, as should those wishing to free living creatures from diseases and thereby earn the deep respect of Buddhist and non-Buddhist practitioners, as well as ordinary people.

At this point the Master of Remedies emitted from the red lotus flower of his tongue numerous multi-coloured rays throughout the ten cardinal directions. Through their blessing living creatures rejected the negativity of mundane speech such as lies idle talk rudeness, slander, and all diseases caused by the imbalance of the three humours were cured while harmful demons were also pacified. Then the rays were reabsorbed and before those present appeared the hermit sage Manasija the emanation of buddha-speech who is essentially the embodiment of the Buddha Amitabha and is endowed with the pristine cognition of discernment (pratyazvksanajnana). After circumambulating the master three times and making obeisance to him he in conformity with the wishes of the all those attending to the Teacher, requested the in order to deliver the second tantra, Bhaisajya-guru enters the contemplation of medicine known as "The Majestic Lion of Speech", emanating from the crown of his head thousands of multicoloured rays of light which immediately cleanse the six classes of living beings of all negativity pertaining to the actions of the body, and alleviate all physical sufferings caused by humoural imbalance. Consequent on the re-absorption of these rays in the crown centre, there emerges Vidyajnana , the emanation of buddha-body who is identified with the nature of Vairocana and endowed with the pristine cognition of reality's expanse (clfinrmadhatujfwfia). At the request of the hermit sage Manasija , Vidyajnana then outlines the eleven topics of the Exegetical Tantra, which provide the theoretical basis for the medical practices condensed in the Root Tantra.

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